Description

Dbco-Peg2-Acid CAS NO 2304558-25-4 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry and a terminal carboxylic acid for further conjugation via amide bond formation. This compound is essential for creating stable, site-specific bioconjugates without the need for cytotoxic copper catalysts, enabling the development of advanced biomaterials and therapeutic agents. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, proteomics, and nanomedicine.

Application

• Bioconjugation and ADC Development: Used as a key linker for coupling cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides via its DBCO and carboxyl groups.
• Proteomics and Biomarker Discovery: Facilitates the labeling and enrichment of azide-tagged biomolecules for mass spectrometry analysis and protein interaction studies.
• Polymer and Biomaterial Synthesis: Serves as a functional building block for creating PEGylated hydrogels, surfaces, and nanoparticles with bio-orthogonal reactivity.
• Diagnostic Reagent Formulation: Employed in the development of immunoassays and imaging probes that require stable, covalent attachment of detection molecules.
• Chemical Biology Tool Development: Enables the creation of activity-based probes and other chemical tools for studying biological processes in live cells.
• Drug Delivery System Optimization: Used to functionalize liposomes, micelles, and other nanocarriers for targeted delivery applications.

Basic Information

Product Name	Dbco-Peg2-Acid
CAS No.	2304558-25-4
Molecular Formula	C27H29N1O6
Molecular Weight	463.53 g/mol
Synonyms	DBCO-PEG2-COOH; DBCO-PEG2-Acid; DBCO-C2-PEG2-Acid; Dibenzocyclooctyne-PEG2-Acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethoxy}ethoxy)acetate; Azadibenzocyclooctyne-PEG2-Acid; ADIBO-PEG2-COOH; 1,3-Dipolar Cycloaddition Reagent
EINECS	Contact for details

Quality Control

Our Dbco-Peg2-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.