Description

1(2H)-Quinolinecarboxylic Acid, 6-Fluoro-3,4-Dihydro-2-Methyl-5-Nitro-, Methyl Ester, (2S)- is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its complex, functionalized quinoline core makes it a valuable building block for constructing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical control. This compound is primarily targeted at R&D chemists and process development scientists within the global pharmaceutical, agrochemical, and fine chemical industries seeking to develop new fluorinated and nitro-substituted heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Research: Serves as a precursor in the development of new-generation herbicides or pesticides leveraging its fluorinated quinoline structure.
• Chemical Biology & Proteomics: Used as a specialized scaffold or tagging reagent in the design of molecular probes and enzyme inhibitors for target validation studies.
• Material Science Research: Potential building block for advanced organic electronic materials or photoactive compounds due to its conjugated nitro-aromatic system.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of complex molecules.
• Academic Research: Used in university and institutional labs for methodological studies in asymmetric synthesis, fluorination chemistry, and heterocyclic compound synthesis.

Basic Information

Product Name	1(2H)-Quinolinecarboxylic Acid, 6-Fluoro-3,4-Dihydro-2-Methyl-5-Nitro-, Methyl Ester, (2S)-
CAS No.	2304372-94-7
Molecular Formula	C12H11FN2O4
Molecular Weight	266.23 g/mol
Synonyms	(2S)-Methyl 6-fluoro-3,4-dihydro-2-methyl-5-nitro-1(2H)-quinolinecarboxylate; (S)-Methyl 6-fluoro-2-methyl-5-nitro-3,4-dihydro-1H-quinoline-1-carboxylate; 6-Fluoro-3,4-dihydro-2-methyl-5-nitro-1(2H)-quinolinecarboxylic acid methyl ester, (2S)-; (2S)-6-Fluoro-3,4-dihydro-2-methyl-5-nitro-1(2H)-quinolinecarboxylic Acid Methyl Ester; (S)-6-Fluoro-2-methyl-5-nitro-3,4-dihydroquinoline-1-carboxylic acid methyl ester; 2304372-94-7; (S)-enantiomer of methyl 6-fluoro-2-methyl-5-nitro-3,4-dihydroquinoline-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1(2H)-Quinolinecarboxylic Acid, 6-Fluoro-3,4-Dihydro-2-Methyl-5-Nitro-, Methyl Ester, (2S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and chiral integrity, meeting the stringent requirements for advanced research intermediates. Certificates of Analysis (COA) detailing specific results for chiral purity (enantiomeric excess), chemical purity (HPLC), and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.