Description

Quinoline, 6-Fluoro-1,2,3,4-Tetrahydro-2-Methyl-5-Nitro-, (2S)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is valued for its role as a key chiral building block in the synthesis of complex, biologically active molecules. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique fluorinated and nitro-substituted tetrahydroquinoline scaffold.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the production of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of chemical probes for studying enzyme function and biological pathways.
• Asymmetric Synthesis: Acts as a chiral template or starting material for the construction of more complex, enantiomerically pure compounds.

Basic Information

Product Name	Quinoline, 6-Fluoro-1,2,3,4-Tetrahydro-2-Methyl-5-Nitro-, (2S)-
CAS No.	2304372-93-6
Molecular Formula	C11H13FN2O2
Molecular Weight	224.23 g/mol
Synonyms	(2S)-6-Fluoro-2-methyl-5-nitro-1,2,3,4-tetrahydroquinoline; (S)-6-Fluoro-2-methyl-5-nitro-1,2,3,4-tetrahydroquinoline; 6-Fluoro-2-methyl-5-nitro-1,2,3,4-tetrahydroquinoline (S-enantiomer); (2S)-6-Fluoro-2-methyl-5-nitro-3,4-dihydro-2H-quinoline; 5-Nitro-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (S); S-6-Fluoro-2-methyl-5-nitro-THQ; Fluoronitrotetrahydroquinoline derivative
EINECS	Contact for details

Quality Control

Our Quinoline, 6-Fluoro-1,2,3,4-Tetrahydro-2-Methyl-5-Nitro-, (2S)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.