Description

1-Ethyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is a specialized heterocyclic building block featuring a tetrahydroquinoline core substituted with an ethyl group and a trifluoromethyl group. This compound is valued for its unique molecular architecture, which combines the structural features of a saturated nitrogen heterocycle with the electron-withdrawing and lipophilicity-enhancing properties of a fluorine substituent. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for use in medicinal chemistry, as a key intermediate in the synthesis of novel active ingredients, and in advanced material science applications.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold in the research and synthesis of new drug candidates, particularly for central nervous system (CNS) targets, anti-infectives, and other therapeutic areas.
• Agrochemical Research: Used in the development of novel pesticides, herbicides, and fungicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Material Science Precursor: Acts as a building block for advanced organic materials, including liquid crystals, organic semiconductors, and functional polymers.
• Chemical Synthesis Reagent: Employed in organic synthesis as a versatile intermediate for constructing more complex nitrogen-containing heterocycles.
• Fluorine Chemistry Studies: Provides a valuable template for investigating structure-activity relationships (SAR) and the effects of fluorination in molecular design.

Basic Information

Item	Detail
Product Name	1-Ethyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline
CAS No.	2288709-48-6
Molecular Formula	C₁₂H₁₄F₃N
Molecular Weight	229.24 g/mol
Synonyms	7-(Trifluoromethyl)-1-ethyl-1,2,3,4-tetrahydroquinoline; 1-Ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-1-ethyl-7-(trifluoromethyl)quinoline; 1-Ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydro-quinoline; ETTHQ (abbreviation); Quinoline, 1-ethyl-1,2,3,4-tetrahydro-7-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Ethyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material is suitable for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.