Description

1-(3-(Difluoromethyl)Isothiazol-5-Yl)-3-(2-Fluoro-5-(Hydroxymethyl)Pyridin-4-Yl)Urea is a sophisticated heterocyclic urea derivative designed for advanced research and development. This compound is of significant interest for its potential as a key synthetic intermediate or active scaffold in the discovery of novel agrochemicals and pharmaceuticals. It is primarily targeted toward R&D chemists and process development scientists in the agrochemical and pharmaceutical industries who require high-purity, structurally complex building blocks.

Application

• Agrochemical Intermediate: Serves as a critical precursor in the synthesis of novel fungicides or herbicides, leveraging its unique difluoromethyl-isothiazole and fluoropyridine motifs.
• Pharmaceutical Research: Acts as a privileged scaffold for medicinal chemistry programs targeting various disease pathways, where the urea linkage can be essential for target binding.
• Chemical Biology Probe: Used in the development of molecular probes to study enzyme function or biological pathways due to its potential for selective interaction.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial production of target active ingredients.
• Custom Synthesis Building Block: Supplied to fine chemical manufacturers for the production of specialized, customer-specific compounds.

Basic Information

Product Name	1-(3-(Difluoromethyl)Isothiazol-5-Yl)-3-(2-Fluoro-5-(Hydroxymethyl)Pyridin-4-Yl)Urea
CAS No.	2270879-17-7
Molecular Formula	C12H9F3N4O2S
Molecular Weight	330.28 g/mol
Synonyms	Urea, N-[3-(difluoromethyl)-5-isothiazolyl]-N'-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]-; 1-(3-(Difluoromethyl)-1,2-thiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea; 2270879-17-7; DFITFPU; Isothiazole-pyridinyl urea derivative; 5-Isothiazolyl urea derivative
EINECS	Contact for details

Quality Control

Our 1-(3-(Difluoromethyl)Isothiazol-5-Yl)-3-(2-Fluoro-5-(Hydroxymethyl)Pyridin-4-Yl)Urea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and KF for moisture content, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.