Description

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-(4-(Difluoromethyl)Phenyl)Propanoic Acid is a high-purity, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This compound serves as a critical building block in the synthesis of complex peptides and peptidomimetics, enabling the exploration of novel therapeutic modalities. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of therapeutic peptides and constrained peptide analogs.
• Drug Discovery Research: Used to incorporate the unique 4-(difluoromethyl)phenyl side chain into peptide sequences to study structure-activity relationships (SAR) and modulate pharmacokinetic properties.
• Peptidomimetic Development: Essential for creating peptide-like molecules with enhanced metabolic stability and bioavailability for potential drug candidates.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for biochemical assays and target identification studies.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scale-up and optimization of synthetic routes for Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-(4-(Difluoromethyl)Phenyl)Propanoic Acid
CAS No.	2255321-52-7
Molecular Formula	C26H23F2NO4
Molecular Weight	451.46 g/mol
Synonyms	Fmoc-N-Me-4-(difluoromethyl)-L-phenylalanine; Fmoc-N-methyl-4-(difluoromethyl)-L-Phe-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(4-(difluoromethyl)phenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-4-(difluoromethyl)-L-phenylalanine; Fmoc-N-Me-(4-(CF2H))-Phe-OH; Nα-Fmoc-Nα-methyl-4-(difluoromethyl)-L-phenylalanine; N-Fmoc-N-methyl-4-difluoromethyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Every batch of our (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-(4-(Difluoromethyl)Phenyl)Propanoic Acid is manufactured and tested under a strict quality management system. We guarantee high chemical purity and chiral integrity, supported by comprehensive analytical data including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.