Description

Fmoc-n-Me-(4-Cf3)-Phe-Oh is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing a trifluoromethylated phenylalanine residue with N-methylation, significantly enhancing the metabolic stability, lipophilicity, and binding affinity of therapeutic peptides. It is an essential building block for pharmaceutical researchers and manufacturers developing novel peptide-based drugs, diagnostic agents, and biochemical tools. The product is supplied to meet the stringent requirements of R&D and cGMP production environments.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy in automated and manual peptide synthesis.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) for oncology, metabolic diseases, and CNS disorders.
• Peptidomimetic Design: Incorporation of the CF3 group and N-methylation to create peptides with improved pharmacokinetic properties and protease resistance.
• Chemical Biology Probes: Synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Potential use in developing novel bioactive peptides for crop protection.
• Academic & Industrial R&D: Fundamental research in medicinal chemistry and peptide science across global institutions.

Basic Information

Product Name	Fmoc-n-Me-(4-Cf3)-Phe-Oh
CAS No.	2255321-51-6
Molecular Formula	C26H22F3NO4
Molecular Weight	469.45 g/mol
Synonyms	Fmoc-N-methyl-4-(trifluoromethyl)-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-4-(trifluoromethyl)-L-phenylalanine; Fmoc-N-Me-(4-CF3)-Phe-OH; Fmoc-N-Me-(4-trifluoromethyl)Phe-OH; N-Fmoc-N-methyl-4-trifluoromethylphenylalanine; Fmoc-N-methyl-4-CF3-L-Phe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-(4-Cf3)-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Keep the container tightly sealed under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.