Description

1-Cyclopropyl-6-Fluoro-8-Hydroxy-7-((4As,7As)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrobromide is a high-purity advanced pharmaceutical intermediate, representing a key structural motif in modern medicinal chemistry. Its primary commercial value lies in its role as a critical building block for the synthesis of novel, potent antibacterial agents, particularly within the fluoroquinolone class. This compound is essential for research and development organizations and active pharmaceutical ingredient (API) manufacturers focused on next-generation anti-infective therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotic candidates targeting resistant bacterial strains.
• Antibacterial Drug Discovery: Used in medicinal chemistry research for structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic profiles.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a critical building block in the multi-step synthesis of complex antibiotic APIs under current Good Manufacturing Practices (cGMP).
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for cost-effective commercial production.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory submissions in drug development pipelines.
• Biochemical Research: Investigated for its mechanism of action and interaction with bacterial DNA gyrase and topoisomerase IV enzymes.

Basic Information

Product Name	1-Cyclopropyl-6-Fluoro-8-Hydroxy-7-((4As,7As)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrobromide
CAS No.	2252446-71-0
Molecular Formula	C20H23BrFN3O4
Molecular Weight	468.32 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-8-hydroxy-7-((4aR,7aR)-hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrobromide; (4aR,7aR)-1-Cyclopropyl-6-fluoro-8-hydroxy-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrobromide; Fluoroquinolone Intermediate HBr Salt; 1-Cyclopropyl-6-fluoro-8-hydroxy-7-((4aR,7aR)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrobromide; Antibacterial Intermediate CAS 2252446-71-0
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-6-Fluoro-8-Hydroxy-7-((4As,7As)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, identity confirmation, and consistent impurity profiles, meeting the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/UPLC) are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.