Description

(2S)-2-(2,4-Difluorophenyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its defined stereochemistry and functionalized pyrrolidine core, which is critical for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the synthesis of fluorinated drug candidates, particularly within therapeutic areas such as central nervous system (CNS) disorders and anti-infectives.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of fluorinated pharmaceutical compounds.
• API Synthesis: Building block for the production of Active Pharmaceutical Ingredients (APIs) targeting neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to enhance drug potency and selectivity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Preclinical Development: Serves as a critical material for producing batches for toxicology and early-stage clinical studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(2S)-2-(2,4-Difluorophenyl)Pyrrolidine Hydrochloride
CAS No.	2250243-07-1
Molecular Formula	C10H12ClF2N
Molecular Weight	219.66 g/mol
Synonyms	(2S)-2-(2,4-Difluorophenyl)pyrrolidine hydrochloride; (S)-2-(2,4-Difluorophenyl)pyrrolidine HCl; 2,4-Difluoro-α-[(2S)-2-pyrrolidinyl]benzene hydrochloride; (S)-2-(2,4-Difluorophenyl)pyrrolidine hydrochloride; Pyrrolidine, 2-(2,4-difluorophenyl)-, hydrochloride, (2S)-; (2S)-2-(2,4-Difluorophenyl)-1-pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (2S)-2-(2,4-Difluorophenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.