Description

cis-2-Aminocyclopentane-1-Carbonitrile Trifluoroacetate is a high-purity, advanced pharmaceutical intermediate featuring a unique cis-configured aminocyclopentane carbonitrile core. This compound is a critical building block in the synthesis of novel, conformationally constrained active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug discovery programs. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing who require reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, especially in protease inhibitor and neurotransmitter modulator research.
• Peptidomimetic Synthesis: Used to construct constrained peptide analogs, enhancing metabolic stability and bioavailability in therapeutic peptides.
• Chemical Biology Probes: Serves as a scaffold for developing enzyme inhibitors and receptor ligands used in biochemical assays and target validation.
• Asymmetric Catalysis Research: Employed as a precursor or ligand in the development of new chiral catalysts for stereoselective synthesis.
• Agrochemical Research: Potential intermediate for creating novel, biologically active compounds with specific stereochemistry.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	cis-2-Aminocyclopentane-1-Carbonitrile Trifluoroacetate
CAS No.	2250241-85-9
Molecular Formula	C8H11F3N2O2
Molecular Weight	224.18 g/mol
Synonyms	cis-2-Aminocyclopentanecarbonitrile TFA salt; (1R,2S)-2-Aminocyclopentane-1-carbonitrile trifluoroacetate; (1S,2R)-2-Aminocyclopentane-1-carbonitrile trifluoroacetate; 2-Aminocyclopentanecarbonitrile trifluoroacetate (cis-); Cyclopentanecarbonitrile, 2-amino-, (1R,2S)-rel-, trifluoroacetate; cis-2-Amino-1-cyanocyclopentane trifluoroacetate; TFA salt of cis-2-Aminocyclopentanecarbonitrile
EINECS	Contact for details

Quality Control

Our cis-2-Aminocyclopentane-1-Carbonitrile Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.