Description

2H-1,4-Benzoxazin-3(4H)-One, 8-[(1R)-2-Bromo-1-Hydroxyethyl]-6-(Phenylmethoxy)- is a high-purity, chiral benzoxazinone derivative, serving as a critical advanced pharmaceutical intermediate (API) for the synthesis of novel therapeutic agents. Its value lies in the precise stereochemistry and functional groups that enable targeted molecular construction in complex organic syntheses. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology sectors, particularly those focused on central nervous system (CNS) and anti-inflammatory drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs) with potential neurological or anti-inflammatory activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Process Chemistry Development: Serves as a standard or starting material for developing and scaling up efficient, GMP-compliant synthetic routes.
• Asymmetric Synthesis: Utilized as a chiral synthon due to its (R)-configured hydroxyethyl side chain for constructing enantiomerically pure compounds.
• Biochemical Research: Potential use as a tool compound or probe for investigating specific enzyme interactions or biological pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	2H-1,4-Benzoxazin-3(4H)-One, 8-[(1R)-2-Bromo-1-Hydroxyethyl]-6-(Phenylmethoxy)-
CAS No.	2248125-51-9
Molecular Formula	C₁₇H₁₆BrNO₄
Molecular Weight	378.22 g/mol
Synonyms	(R)-8-(2-Bromo-1-hydroxyethyl)-6-(benzyloxy)-2H-1,4-benzoxazin-3(4H)-one; 8-[(1R)-2-Bromo-1-Hydroxyethyl]-6-(Phenylmethoxy)-4H-1,4-Benzoxazin-3-One; 6-(Benzyloxy)-8-[(1R)-2-bromo-1-hydroxyethyl]-2H-1,4-benzoxazin-3(4H)-one; Benzoxazinone derivative CAS 2248125-51-9; Chiral Bromo-Hydroxyethyl Benzoxazinone; Advanced Benzoxazinone Intermediate
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and chiral integrity meet the exacting standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing results from HPLC, chiral analysis, NMR, and other relevant tests are supplied with each shipment. Our quality commitment aligns with ICH guidelines, and custom synthesis can be performed under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.