Description

(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-(Pyridin-4-Yl)Propanoic Acid is a sophisticated, non-natural amino acid derivative featuring a pyridyl side chain and an Fmoc-protected, N-methylated backbone. This compound matters as a critical building block in modern peptide synthesis, enabling the introduction of structural complexity, enhanced metabolic stability, and specific binding motifs into peptide sequences. Pharmaceutical researchers and peptide manufacturers need this high-purity intermediate for developing novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid monomer for the automated synthesis of complex peptides, particularly where N-methylation is required to modulate conformation and bioavailability.
• Peptidomimetic Drug Discovery: Used to incorporate a rigid, aromatic pyridine moiety and N-methylation into peptide backbones, creating analogs with improved receptor selectivity and resistance to enzymatic degradation.
• Chemical Biology & Probe Development: Serves as a versatile scaffold for constructing activity-based probes, affinity tags, or labeled peptides for target identification and mechanism-of-action studies.
• Pharmaceutical Intermediate: An essential raw material in the research and development pipeline for novel peptide-based therapeutics targeting GPCRs, enzymes, and protein-protein interactions.
• Academic Research: Employed in university and institutional labs for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-(Pyridin-4-Yl)Propanoic Acid
CAS No.	2243125-97-3
Molecular Formula	C24H22N2O4
Molecular Weight	402.45 g/mol
Synonyms	Fmoc-N-Me-4-Pal-OH; Fmoc-N-methyl-4-pyridylalanine; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]-3-(4-pyridinyl)propanoic acid; Fmoc-N-Me-(4-Pyridyl)-Ala-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-4-pyridylalanine; Nα-Fmoc-Nα-methyl-4-pyridylalanine; Fmoc-N-methyl-4-Pal; N-Fmoc-N-methyl-3-(4-pyridyl)-D-alanine
EINECS	Contact for details

Quality Control

Our (2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-(Pyridin-4-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical specifications to ensure the material meets the stringent requirements for peptide synthesis and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., argon or nitrogen) when not in use to maintain stability and purity. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.