Description

7-Bromo-8-Fluoro-6-Iodoquinazoline-2,4(1H,3H)-Dione is a high-value, multi-halogenated quinazoline derivative, a crucial advanced intermediate in modern pharmaceutical research and development. Its complex halogenated structure makes it a key building block for synthesizing novel, targeted small-molecule drug candidates, particularly in oncology and kinase inhibitor discovery. This compound is essential for medicinal chemists and R&D teams in pharmaceutical and biotechnology companies seeking to develop next-generation therapeutics with enhanced potency and selectivity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and enzyme functions.
• Active Pharmaceutical Ingredient (API) Development: Employed in the synthetic route for developing new chemical entities (NCEs) under clinical investigation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug design.

Basic Information

Product Name	7-Bromo-8-Fluoro-6-Iodoquinazoline-2,4(1H,3H)-Dione
CAS No.	2241721-74-2
Molecular Formula	C8H3BrFINO2
Molecular Weight	395.92 g/mol
Synonyms	7-Bromo-8-fluoro-6-iodo-1H,3H-quinazoline-2,4-dione; 6-Iodo-7-bromo-8-fluoroquinazoline-2,4(1H,3H)-dione; 2,4(1H,3H)-Quinazolinedione, 7-bromo-8-fluoro-6-iodo-; 7-Bromo-8-fluoro-6-iodo-2,4-dihydroxyquinazoline; CAS 2241721-74-2
EINECS	Contact for details

Quality Control

Our 7-Bromo-8-Fluoro-6-Iodoquinazoline-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality assurance supports the stringent requirements of pharmaceutical R&D and cGMP-compliant applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.