Description

21-Chloro-3,6,9,12,15-Pentaoxahenicosan-1-Amine Hydrochloride is a high-purity, functionalized polyethylene glycol (PEG) derivative, specifically a chloro-terminated PEG amine hydrochloride salt. This compound is engineered to serve as a critical heterobifunctional linker and building block in advanced bioconjugation and materials science applications. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and nanotechnology sectors who require reliable, high-quality intermediates for creating targeted drug delivery systems, diagnostic agents, and functionalized surfaces.

Application

• Bioconjugation and PEGylation: A key reagent for attaching therapeutic proteins, peptides, or small molecule drugs to PEG chains to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Linker for Antibody-Drug Conjugates (ADCs): Used as a functional spacer to connect cytotoxic payloads to monoclonal antibodies, enabling targeted cancer therapy.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, or solid supports with amine-reactive groups for subsequent coupling of biomolecules or ligands.
• Polymer Chemistry: Acts as a macroinitiator or monomer in the synthesis of specialized block copolymers and hydrogels with tailored properties.
• Diagnostic Reagent Synthesis: Utilized in the development of contrast agents and fluorescent probes for imaging applications.
• Cross-linking Agent: Serves as a heterobifunctional cross-linker for coupling molecules containing different functional groups (e.g., thiols, carboxyls).

Basic Information

Product Name	21-Chloro-3,6,9,12,15-Pentaoxahenicosan-1-Amine Hydrochloride
CAS No.	2241669-16-7
Molecular Formula	C15H33Cl2NO5
Molecular Weight	378.33 g/mol
Synonyms	21-Chloro-3,6,9,12,15-pentaoxahenicosan-1-amine hydrochloride; Amino-PEG5-Chloro hydrochloride; α-Chloro-ω-amino PEG5 hydrochloride; 2-[2-[2-[2-[2-(2-Chloroethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethylamine hydrochloride; 19-Amino-4,7,10,13,16-pentaoxanonadec-1-yl chloride hydrochloride; PEG5 Amine Chloride Hydrochloride; Amine-PEG5-CL HCl; Heterobifunctional PEG linker, chloro-amine, HCl salt
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical-grade intermediates. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications and test results are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.