Description

Quinoline, 3-Bromo-8-(Trifluoromethoxy)- is a specialized halogenated and trifluoromethoxy-substituted quinoline derivative, serving as a high-value building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines bromine's reactivity for cross-coupling with the electron-withdrawing and lipophilicity-enhancing trifluoromethoxy group. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients, particularly in medicinal chemistry for hit-to-lead optimization.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in developing advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or ligand in the creation of functional organic materials, such as OLEDs or conductive polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Ligand Synthesis for Catalysis: Used to prepare novel nitrogen-containing ligands for transition metal catalysts.

Basic Information

Item	Detail
Product Name	Quinoline, 3-Bromo-8-(Trifluoromethoxy)-
CAS No.	2241594-65-8
Molecular Formula	C₁₀H₅BrF₃NO
Molecular Weight	292.05 g/mol
Synonyms	3-Bromo-8-(trifluoromethoxy)quinoline; 8-(Trifluoromethoxy)-3-bromoquinoline; 3-Bromo-8-trifluoromethoxyquinoline; Quinoline, 3-bromo-8-(trifluoromethoxy)-; 2241594-65-8; 3-Br-8-OCF3-Quinoline
EINECS	Contact for details

Quality Control

Every batch of Quinoline, 3-Bromo-8-(Trifluoromethoxy)- is produced and tested under a strict quality management system. We ensure compliance with high-purity research-grade standards, with typical purity levels exceeding 95% (HPLC). Identity and purity are confirmed via NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.