Description

Spiro[Cyclopropane-1,1'-[1H]Isoindol]-3'(2'H)-One, 6'-Bromo- is a high-value, advanced pharmaceutical intermediate characterized by its unique spirocyclic and brominated isoindolone structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for potential APIs under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and protein functions due to its ability to modulate protein-protein interactions.
• Agrochemical Research: Potential application as an intermediate in the discovery of new agrochemicals with novel modes of action.
• Academic Research: Employed in university and institutional labs for methodological studies in organic synthesis, particularly in spirocycle formation and halogenated heterocycle chemistry.

Basic Information

Product Name	Spiro[Cyclopropane-1,1'-[1H]Isoindol]-3'(2'H)-One, 6'-Bromo-
CAS No.	2241580-81-2
Molecular Formula	C10H8BrNO
Molecular Weight	238.08 g/mol
Synonyms	6'-Bromospiro[cyclopropane-1,1'-isoindol]-3'(2'H)-one; 6'-Bromo-1'H-spiro[cyclopropane-1,2'-isoindol]-3'-one; 6'-Bromospiro[isoindole-1,1'-cyclopropan]-3-one; 6-Bromo-spiro(cyclopropane-1,1'-isoindolin)-3'-one; Brominated Spirocyclic Isoindolinone; Advanced Brominated Spiro Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopropane-1,1'-[1H]Isoindol]-3'(2'H)-One, 6'-Bromo- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where required, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere when appropriate for long-term stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.