Description

4-Fluoro-4-(Trifluoromethyl)Piperidine Hydrochloride is a high-value, fluorinated piperidine derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both fluorine and a trifluoromethyl group, makes it an essential intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential CNS drugs and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine motifs enhance biological activity and environmental persistence.
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals that require fluorinated components for specific thermal or chemical resistance properties.
• Medicinal Chemistry: Serves as a versatile scaffold for constructing compound libraries via parallel synthesis for high-throughput screening (HTS) campaigns.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and protein-ligand interactions.

Basic Information

Product Name	4-Fluoro-4-(Trifluoromethyl)Piperidine Hydrochloride
CAS No.	2241140-83-8
Molecular Formula	C6H10ClF4N
Molecular Weight	207.60 g/mol
Synonyms	4-Fluoro-4-(trifluoromethyl)piperidine HCl; 4-Fluoro-α,α,α-trifluoro-4-piperidinemethanol hydrochloride; 4-(Trifluoromethyl)-4-fluoropiperidine hydrochloride; Piperidine, 4-fluoro-4-(trifluoromethyl)-, hydrochloride; 4-Fluoro-4-trifluoromethylpiperidine hydrochloride; 2241140-83-8
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-4-(Trifluoromethyl)Piperidine Hydrochloride is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.