Description

(1R)-1-[3-(Difluoromethyl)Phenyl]Ethylamine Hcl is a high-purity chiral amine building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules with precise stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel compounds and process optimization.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Serves as a key building block in the production of advanced herbicides, fungicides, and insecticides that require specific stereochemistry for optimal efficacy.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands and organocatalysts for asymmetric synthesis, enabling more efficient and selective chemical transformations.
• Fine Chemical Manufacturing: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic and Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in medicinal chemistry and process chemistry laboratories.
• Peptidomimetic Research: Acts as a non-natural amino acid analogue for the design and synthesis of novel peptidomimetics and bioactive peptides.

Basic Information

Product Name	(1R)-1-[3-(Difluoromethyl)Phenyl]Ethylamine Hydrochloride
CAS No.	2230840-55-6
Molecular Formula	C9H12ClF2N
Molecular Weight	207.65 g/mol
Synonyms	(R)-1-(3-(Difluoromethyl)phenyl)ethan-1-amine hydrochloride; (1R)-1-[3-(Difluoromethyl)phenyl]ethanamine hydrochloride; (R)-α-Methyl-3-(difluoromethyl)benzylamine hydrochloride; (R)-1-(3-(Difluoromethyl)phenyl)ethylamine HCl; (R)-3'-(Difluoromethyl)amphetamine hydrochloride; (R)-1-Amino-1-(3-(difluoromethyl)phenyl)ethane hydrochloride; (R)-DFMPA HCl
EINECS	Contact for details

Quality Control

Our (1R)-1-[3-(Difluoromethyl)Phenyl]Ethylamine Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.