Description

(S)-7-Methoxy-2-Methyl-6-((Tetrahydrofuran-3-Yl)Oxy)Quinazolin-4(3H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and quinazolinone core structure. This compound is of significant value in medicinal chemistry for the research and development of targeted therapeutic agents. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel drug candidates, particularly in oncology and other disease areas where kinase inhibition is a key mechanism of action.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, potent kinase inhibitors for targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug candidate efficacy and selectivity.
• Preclinical Drug Development: Serves as a critical starting material for producing compounds for in vitro and in vivo biological testing.
• Process Chemistry: Employed in route scouting and scale-up optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the biopharma industry.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(S)-7-Methoxy-2-Methyl-6-((Tetrahydrofuran-3-Yl)Oxy)Quinazolin-4(3H)-One
CAS No.	2230840-12-5
Molecular Formula	C15H18N2O4
Molecular Weight	290.32 g/mol
Synonyms	(S)-7-Methoxy-2-methyl-6-((tetrahydrofuran-3-yl)oxy)-3,4-dihydroquinazolin-4-one; (S)-6-((Tetrahydrofuran-3-yl)oxy)-7-methoxy-2-methylquinazolin-4(3H)-one; (S)-enantiomer of a quinazolinone kinase inhibitor intermediate; UNII-Contact for details; (3S)-7-Methoxy-2-methyl-6-[(oxolan-3-yl)oxy]-3H-quinazolin-4-one; 4(3H)-Quinazolinone, 7-methoxy-2-methyl-6-[(3S)-tetrahydro-3-furanyl]oxy]-
EINECS	Contact for details

Quality Control

Our (S)-7-Methoxy-2-Methyl-6-((Tetrahydrofuran-3-Yl)Oxy)Quinazolin-4(3H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.