Description

2，2-Difluoro-1-(4-(Trifluoromethoxy)Phenyl)Cyclopropane-1-Carboxylic Acid is a high-value, multifunctional fluorinated cyclopropane derivative. This compound serves as a critical advanced intermediate in the synthesis of complex molecules, prized for its unique structural motif that imparts desirable metabolic stability and lipophilicity. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, where the difluorocyclopropane and trifluoromethoxy groups enhance biological activity.
• Material Science Precursor: Serves as a monomer or functionalizing agent for developing specialty polymers with enhanced chemical resistance and unique surface properties.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create chiral ligands or metal-organic frameworks (MOFs) for asymmetric catalysis.
• Fluorine Chemistry Research: An important substrate for studying structure-activity relationships (SAR) and novel fluorination reactions in academic and industrial R&D.
• Liquid Crystal & Electronic Materials: Potential intermediate for synthesizing fluorinated components used in display technologies and organic electronics.

Basic Information

Item	Details
Product Name	2，2-Difluoro-1-(4-(Trifluoromethoxy)Phenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	2229533-86-0
Molecular Formula	C11H7F5O3
Molecular Weight	282.16 g/mol
Synonyms	2,2-Difluoro-1-[4-(trifluoromethoxy)phenyl]cyclopropane-1-carboxylic acid; 1-(4-(Trifluoromethoxy)phenyl)-2,2-difluorocyclopropanecarboxylic acid; α,α-Difluoro-4-(trifluoromethoxy)benzenecyclopropanecarboxylic acid; Difluorotrifluoromethoxyphenyl cyclopropanecarboxylic acid; CAS 2229533-86-0; F5-cyclopropane carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 2，2-Difluoro-1-(4-(Trifluoromethoxy)Phenyl)Cyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acid nature, store separately from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.