Description

trans-2-(3-Chloro-5-Fluorophenyl)Cyclopropan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its cyclopropane amine core with a halogenated aromatic substituent. This compound is critical for medicinal chemistry research and development, serving as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and anti-infective drugs.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained cyclopropane ring and halogenated phenyl group.
• API Development: Serves as a key building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs), especially in neurological and psychiatric drug discovery.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme function and receptor interactions in biological systems.
• Asymmetric Synthesis: Utilized as a chiral amine component in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	trans-2-(3-Chloro-5-Fluorophenyl)Cyclopropan-1-Amine Hydrochloride
CAS No.	2227914-40-9
Molecular Formula	C9H10Cl2FN
Molecular Weight	234.09 g/mol
Synonyms	(1R,2S)-2-(3-Chloro-5-fluorophenyl)cyclopropan-1-amine hydrochloride; (1S,2R)-2-(3-Chloro-5-fluorophenyl)cyclopropan-1-amine hydrochloride; trans-2-(3-Chloro-5-fluorophenyl)cyclopropylamine HCl; 2-(3-Chloro-5-fluorophenyl)cyclopropanamine hydrochloride; 1-Cyclopropanamine, 2-(3-chloro-5-fluorophenyl)-, hydrochloride, (1R,2S)-rel-; 2227914-40-9; 3-Chloro-5-fluorophenylcyclopropylamine hydrochloride.
EINECS	Contact for details

Quality Control

Our trans-2-(3-Chloro-5-Fluorophenyl)Cyclopropan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment aligns with ICH guidelines for impurities in drug substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under anhydrous conditions to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.