Description

trans-2-(3-Fluoro-5-(Trifluoromethyl)Phenyl)Cyclopropane-1-Carboxylic Acid is a high-value, multifunctional cyclopropane carboxylic acid derivative, distinguished by its unique fluorinated aromatic substitution pattern. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry, enabling the introduction of a rigid, three-membered ring system with tailored electronic properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and metabolic disease research.
• Agrochemical Synthesis: Used as a building block for creating new-generation herbicides and pesticides with enhanced efficacy and environmental profiles.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into specialty polymers and liquid crystals to modify thermal stability and optical properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and fragment-based drug discovery due to its constrained geometry and fluorine atoms.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring this precise fluorinated motif.

Basic Information

Product Name	trans-2-(3-Fluoro-5-(Trifluoromethyl)Phenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	2227793-92-0
Molecular Formula	C11H8F4O2
Molecular Weight	248.18 g/mol
Synonyms	(1R,2S)-2-[3-Fluoro-5-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid; (1S,2R)-2-[3-Fluoro-5-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid; trans-2-(3-Fluoro-5-(trifluoromethyl)phenyl)cyclopropanecarboxylic acid; 2-(3-Fluoro-5-(trifluoromethyl)phenyl)cyclopropanecarboxylic acid; 2227793-92-0; 3-Fluoro-5-(trifluoromethyl)phenylcyclopropanecarboxylic acid; Fluorinated Cyclopropane Carboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our production of trans-2-(3-Fluoro-5-(Trifluoromethyl)Phenyl)Cyclopropane-1-Carboxylic Acid adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements, supporting development under cGMP guidelines where needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.