Description

3-Amino-1-Phenylcyclobutan-1-Ol Hydrochloride is a high-purity, pharmaceutically relevant building block used in modern organic synthesis. This compound is valued for its unique cyclobutane core functionalized with both amino and hydroxyl groups, making it a versatile chiral intermediate for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic candidates, particularly in areas targeting central nervous system (CNS) disorders and other complex disease pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for neurological and psychiatric targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its constrained cyclobutane ring and multiple functional handles.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate in the development of scalable, GMP-compliant synthetic routes for clinical trial material.
• Chemical Biology Probes: Employed in the synthesis of specialized molecular probes and tool compounds for investigating biological pathways and target engagement.
• Academic & Institutional Research: Used in universities and research institutes for methodological studies in asymmetric synthesis and the exploration of novel chemical space.
• Custom Synthesis & Contract Manufacturing: A critical building block for fine chemical suppliers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	3-Amino-1-Phenylcyclobutan-1-Ol Hydrochloride
CAS No.	2227206-63-3
Molecular Formula	C10H14ClNO
Molecular Weight	199.68 g/mol
Synonyms	1-Phenyl-3-aminocyclobutanol Hydrochloride; 3-Amino-1-phenylcyclobutan-1-ol HCl; (±)-3-Amino-1-phenylcyclobutanol hydrochloride; 1-Cyclobutanol, 3-amino-1-phenyl-, hydrochloride; 3-Amino-1-phenyl-1-cyclobutanol hydrochloride; 1-Phenyl-3-aminocyclobutyl-1-ol hydrochloride; 3-Amino-1-phenylcyclobutanol hydrochloride salt
EINECS	Contact for details

Quality Control

Our 3-Amino-1-Phenylcyclobutan-1-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results. We support development with regulatory starting material (RSM) documentation packages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.