Description

1-(2-Fluorocyclobutyl)Methanamine Hydrochloride is a high-purity, synthetically valuable fluorinated amine salt used as a critical building block in advanced organic synthesis. Its unique fluorocyclobutyl structure makes it a versatile intermediate for developing novel pharmaceutical candidates and agrochemicals, offering opportunities for molecular property modulation. This compound is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with potential biological activity.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorocyclobutyl moiety can enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis, leveraging the amine functionality for complex molecule construction.
• Peptidomimetics & Bioisosteres: The fluorinated cyclobutane ring acts as a bioisostere for other cyclic systems, useful in designing peptide mimics and optimizing drug-like properties.
• Material Science Precursor: Potential use in synthesizing specialty monomers or functionalized polymers with unique surface properties or fluorine content.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme mechanisms or protein-ligand interactions due to its modifiable amine handle.

Basic Information

Item	Detail
Product Name	1-(2-Fluorocyclobutyl)Methanamine Hydrochloride
CAS No.	2227206-43-9
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol
Synonyms	(2-Fluorocyclobutyl)methanamine hydrochloride; 1-(2-Fluorocyclobutyl)methylamine HCl; 2-Fluorocyclobutanemethanamine hydrochloride; (2-Fluorocyclobutyl)methylammonium chloride; 1-Aminomethyl-2-fluorocyclobutane hydrochloride; 2-Fluoro-1-(aminomethyl)cyclobutane hydrochloride; FCBMA-HCl
EINECS	Contact for details

Quality Control

Our 1-(2-Fluorocyclobutyl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.