Description

(S)-3-(Trifluoromethyl)Pyrrolidine Hydrochloride is a high-value, chiral building block and intermediate of significant importance in modern pharmaceutical and agrochemical research. Its core value lies in the combination of the rigid pyrrolidine scaffold with the metabolically stable trifluoromethyl group, enabling the fine-tuning of biological activity and physicochemical properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, especially in medicinal chemistry programs for CNS targets, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands in asymmetric catalysis, facilitating the synthesis of enantiomerically pure compounds.
• Peptidomimetics and Bioisosteres: The pyrrolidine ring acts as a proline bioisostere, useful in designing peptide analogs with improved metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and protein function.
• Material Science Research: Investigated as a component in the synthesis of specialty polymers and advanced organic materials with unique properties.

Basic Information

Product Name	(S)-3-(Trifluoromethyl)Pyrrolidine Hydrochloride
CAS No.	2227198-24-3
Molecular Formula	C5H9ClF3N
Molecular Weight	175.58 g/mol
Synonyms	(S)-3-(Trifluoromethyl)pyrrolidine HCl; (S)-3-(Trifluoromethyl)pyrrolidine hydrochloride; (3S)-3-(Trifluoromethyl)pyrrolidine hydrochloride; Pyrrolidine, 3-(trifluoromethyl)-, hydrochloride, (3S)-; (S)-3-Trifluoromethylpyrrolidine HCl Salt; (S)-3-CF3-Pyrrolidine HCl
EINECS	Contact for details

Quality Control

Our (S)-3-(Trifluoromethyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for advanced research and development. Certificates of Analysis (COA) providing detailed results for assay, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.