Description

Bis(tert-Butyl n-[(3R,4S)-4-Methoxypiperidin-3-Yl]Carbamate) CAS NO 2227197-47-7 is a high-purity, chiral piperidine derivative used as a critical building block in advanced organic synthesis. This compound is essential for pharmaceutical research and development, particularly in the creation of novel active pharmaceutical ingredients (APIs) with specific stereochemical requirements. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the methoxypiperidine pharmacophore.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development for GMP manufacturing.
• Agrochemical Synthesis: Employed in the research and production of advanced, stereospecific pesticides and herbicides.
• Ligand and Catalyst Preparation: Useful for constructing chiral ligands for asymmetric catalysis.
• Academic Research: A valuable reagent for methodological studies in organic synthesis and stereochemistry at universities and R&D institutes.

Basic Information

Product Name	Bis(tert-Butyl n-[(3R,4S)-4-Methoxypiperidin-3-Yl]Carbamate)
CAS No.	2227197-47-7
Molecular Formula	C₂₂H₄₁N₃O₆
Molecular Weight	443.58 g/mol
Synonyms	1,1'-((3R,4S)-4-Methoxypiperidine-3,3-diyl)bis(2-methylpropan-2-yl) dicarbamate; tert-Butyl ((3R,4S)-4-methoxypiperidin-3-yl)carbamate dimer; (3R,4S)-3-((tert-Butoxycarbonyl)amino)-4-methoxypiperidine carbamate derivative; BOC-protected 4-methoxy-3-aminopiperidine dimer; (3R,4S)-N-Boc-4-methoxy-3-aminopiperidine carbamate
EINECS	Contact for details

Quality Control

Our Bis(tert-Butyl n-[(3R,4S)-4-Methoxypiperidin-3-Yl]Carbamate) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can support development toward cGMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.