Description

(3S)-3-(Fluoromethyl)Pyrrolidine Hydrochloride CAS NO 2227197-34-2 is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its defined stereochemistry and the presence of a fluoromethyl group, which are critical for modulating the biological activity, metabolic stability, and lipophilicity of target drug molecules. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those working on novel therapeutics in central nervous system (CNS) disorders, oncology, and other life science areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization, especially where fluorine substitution is desired.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in linker or ligand design for bifunctional degrader molecules.
• Agrochemical Synthesis: Potential intermediate in the development of advanced pesticides and herbicides with improved efficacy.
• Ligand for Catalysis: Can be utilized in the development of chiral ligands for asymmetric synthesis.
• Bioconjugation & Chemical Biology: Employed in the modification of biomolecules or as a handle for probe development.

Basic Information

Product Name	(3S)-3-(Fluoromethyl)Pyrrolidine Hydrochloride
CAS No.	2227197-34-2
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol
Synonyms	(3S)-3-(Fluoromethyl)pyrrolidine HCl; (S)-3-(Fluoromethyl)pyrrolidine hydrochloride; (S)-3-Fluoromethylpyrrolidine HCl; Pyrrolidine, 3-(fluoromethyl)-, hydrochloride (1:1), (3S)-; 2227197-34-2; (S)-3-(Fluoromethyl)pyrrolidine, hydrochloride; (3S)-3-(Fluoromethyl)-1-azabicyclo[3.1.0]hexane hydrochloride (incorrect but related bicyclic form); UNII- (Contact for details)
EINECS	Contact for details

Quality Control

Our (3S)-3-(Fluoromethyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.