Description

cis-2-Methoxycyclobutan-1-Amine Hydrochloride is a high-purity, synthetically valuable chiral amine salt. This compound serves as a critical building block in modern pharmaceutical research and development, offering a constrained cyclobutane scaffold with defined stereochemistry. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of new drug candidates targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Agrochemical Research: Building block for creating novel pesticides and herbicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Synthesis: Precursor for the preparation of chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Used in the synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Peptidomimetics: Incorporation into peptide backbones to create conformationally restricted analogs with improved metabolic stability.
• Academic Research: Valuable reagent for methodological development in organic synthesis and stereochemistry studies.

Basic Information

Product Name	cis-2-Methoxycyclobutan-1-Amine Hydrochloride
CAS No.	2227197-30-8
Molecular Formula	C5H12ClNO
Molecular Weight	137.61 g/mol
Synonyms	cis-2-Methoxycyclobutanamine hydrochloride; (1R,2S)-2-Methoxycyclobutan-1-amine hydrochloride; (1S,2R)-2-Methoxycyclobutan-1-amine hydrochloride; 2-Methoxycyclobutan-1-amine hydrochloride (cis-); Cyclobutanamine, 2-methoxy-, hydrochloride, cis-; 1-Amino-2-methoxycyclobutane hydrochloride (cis-); 2227197-30-8; cis-2-Methoxy-1-aminocyclobutane HCl
EINECS	Contact for details

Quality Control

Our cis-2-Methoxycyclobutan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.