Description

Cyclobutanamine, 2-Methoxy-, Hydrochloride (1:1), (1R,2R)-Rel- is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals, where its specific stereochemistry is critical for biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex molecules for drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore novel chemical space.
• Process Chemistry & Scale-up: Serves as a defined starting material for the pilot and commercial-scale synthesis of target molecules under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric transformations to construct complex, enantiomerically pure molecular architectures.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or molecular probes for studying biological pathways and target engagement.
• Agrochemical Research: Potential intermediate in the development of new, stereospecific pesticides and herbicides.

Basic Information

Product Name	Cyclobutanamine, 2-Methoxy-, Hydrochloride (1:1), (1R,2R)-Rel-
CAS No.	2226828-67-5
Molecular Formula	C5H12ClNO
Molecular Weight	137.61 g/mol (Free base: C5H11NO)
Synonyms	(1R,2R)-rel-2-Methoxycyclobutanamine Hydrochloride; rel-(1R,2R)-2-Methoxycyclobutan-1-amine Hydrochloride; (1R,2R)-2-Methoxycyclobutanamine HCl; 2-Methoxycyclobutanamine Hydrochloride (rel-(1R,2R)-form); Cyclobutanamine, 2-methoxy-, hydrochloride, (1R,2R)-rel-; (1R,2R)-2-Methoxy-1-aminocyclobutane Hydrochloride
EINECS	Contact for details

Quality Control

Our Cyclobutanamine, 2-Methoxy-, Hydrochloride (1:1), (1R,2R)-Rel- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We employ advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry to verify identity, stereochemical purity, and chemical purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.