Description

(S)-2,2,2-Trifluoro-1-(Naphthalen-1-Yl)Ethanamine Hydrochloride is a chiral, fluorinated amine building block of significant interest in advanced organic synthesis. This compound is valued for its role in introducing the trifluoromethyl group and a naphthyl moiety into molecular frameworks, which can dramatically alter physicochemical properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in creating advanced, fluorinated active ingredients for crop protection products, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry in complex reactions.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials where fluorinated aromatic components are required for specific electronic or surface properties.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in research due to the distinct properties imparted by the fluorine atoms and the naphthalene fluorophore.

Basic Information

Product Name	(S)-2,2,2-Trifluoro-1-(Naphthalen-1-Yl)Ethanamine Hydrochloride
CAS No.	2222662-58-8
Molecular Formula	C₁₂H₁₁ClF₃N
Molecular Weight	261.67 g/mol
Synonyms	(S)-1-(1-Naphthyl)-2,2,2-trifluoroethylamine hydrochloride; (S)-α-(1-Naphthyl)-2,2,2-trifluoroethylamine HCl; (S)-1-(Naphthalen-1-yl)-2,2,2-trifluoroethanamine hydrochloride; (S)-TFNE·HCl; (S)-1-(1-Naphthyl)-2,2,2-trifluoroethanaminium chloride; (S)-2,2,2-Trifluoro-1-(1-naphthyl)ethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-(Naphthalen-1-Yl)Ethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process chemistry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.