Description

(1S,6R)-8-Methyl-3,8-Diazabicyclo[4.2.0]Octane Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and other therapeutic agents. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in process development and scale-up of new drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules targeting neurological disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Process Chemistry & Scale-Up: Serves as a defined starting material or intermediate for kilogram-to-ton scale GMP manufacturing campaigns.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecular architectures due to its rigid bicyclic and chiral nature.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Product Name	(1S,6R)-8-Methyl-3,8-Diazabicyclo[4.2.0]Octane Dihydrochloride
CAS No.	2221988-52-7
Molecular Formula	C8H16N2·2HCl
Molecular Weight	213.14 g/mol
Synonyms	8-Methyl-3,8-diazabicyclo[4.2.0]octane dihydrochloride, (1S,6R)-isomer; (1S,6R)-8-Methyl-3,8-diazabicyclo[4.2.0]octane hydrochloride; Tropane derivative dihydrochloride; Bicyclic diamine salt; (1S,6R)-8-Methyl-3,8-diazabicyclo[4.2.0]octane, 2HCl; 3,8-Diazabicyclo[4.2.0]octane, 8-methyl-, dihydrochloride, (1S,6R)-
EINECS	Contact for details

Quality Control

Our (1S,6R)-8-Methyl-3,8-Diazabicyclo[4.2.0]Octane Dihydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical development. A detailed Certificate of Analysis (COA) providing full chromatographic and spectroscopic data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.