Description

Mal-Peg4-Amine Tfa Salt is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and a primary amine, separated by a tetraethylene glycol spacer, and presented as a trifluoroacetate salt. This compound is essential for creating stable, site-specific bioconjugates, particularly in antibody-drug conjugate (ADC) development and protein-polymer conjugation. It is primarily utilized by researchers and process development scientists in the pharmaceutical, biotechnology, and diagnostics industries who require precise and reproducible linker chemistry.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Construction: The maleimide group enables thiol-selective conjugation to cysteine residues on antibodies, while the amine facilitates coupling to payloads containing activated esters (e.g., NHS esters).
• Site-Specific Protein/Peptide Modification: Used to introduce PEG chains or functional tags onto specific sites of proteins or peptides to enhance stability, solubility, or pharmacokinetic properties.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, or solid supports with amine-reactive groups via the maleimide moiety for subsequent biomolecule immobilization.
• Dendrimer and Polymer Synthesis: Serves as a versatile building block in the stepwise synthesis of branched polymers and dendrimers due to its two distinct reactive groups.
• Diagnostic Reagent Preparation: Used in the development of enzyme-linked or fluorescently labeled immunoassay components through controlled conjugation strategies.

Basic Information

Product Name	Mal-Peg4-Amine Tfa Salt
CAS No.	2221042-92-6
Molecular Formula	C₂₀H₃₃F₃N₂O₉
Molecular Weight	502.5 g/mol
Synonyms	Maleimide-PEG4-amine TFA salt; 3-[2-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propylamine trifluoroacetate; 1-[2-[2-[2-[2-(3-Aminopropoxy)ethoxy]ethoxy]ethoxy]ethyl]-1H-pyrrole-2,5-dione trifluoroacetate; Amine-PEG4-maleimide TFA salt; MAL-PEG4-NH2.TFA; mPEG4-MAL-amine TFA; N-(3-Aminopropyl)maleimide-PEG4 TFA salt
EINECS	Contact for details

Quality Control

Our Mal-Peg4-Amine Tfa Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.