Description

4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Piperidine Hydrochloride is a specialized, high-value chemical building block featuring a reactive diazirine photoaffinity label. This compound is critical for advanced research and development in chemical biology and medicinal chemistry, enabling precise cross-linking studies for target identification and protein-ligand interaction mapping. It is primarily utilized by pharmaceutical R&D teams, agrochemical innovators, and academic research institutions focused on photochemistry and probe development.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent capture of transient biomolecular interactions in drug discovery.
• Chemical Biology Probes: Synthesis of activity-based probes (ABPs) for target deconvolution and mechanism-of-action studies.
• Proteomics Research: Used to create photo-crosslinkers for identifying protein-protein and protein-small molecule interactions.
• Medicinal Chemistry: Incorporation into lead compounds to create irreversible inhibitors or to study binding sites.
• Material Science: Potential use in surface functionalization and polymer cross-linking via photochemical activation.
• Agrochemical Research: Development of novel bioactive compounds with specific modes of action.

Basic Information

Product Name	4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Piperidine Hydrochloride
CAS No.	2219407-49-3
Molecular Formula	C7H9F3N3 • HCl
Molecular Weight	231.62 g/mol (Free base: 195.16 g/mol)
Synonyms	4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)piperidine hydrochloride; 3-(Piperidin-4-yl)-3-(trifluoromethyl)-3H-diazirine hydrochloride; 4-(3-Trifluoromethyl-3H-diazirin-3-yl)piperidine HCl; Trifluoromethyldiazirine Piperidine Hydrochloride; PAL Piperidine Reagent; Photoaffinity Labeling Building Block; TFDZ-Piperidine HCl
EINECS	Contact for details

Quality Control

Every batch of 4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Piperidine Hydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical purity and stability, supported by comprehensive analytical characterization including NMR, HPLC, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic and light-sensitive nature, the product should be handled under inert atmosphere (e.g., nitrogen or argon) when opening for prolonged periods and desiccated for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.