Description

Bocnh-Peg12-Oh CAS NO 2218463-36-4 is a specialized polyethylene glycol (PEG)-based linker molecule featuring a tert-butyloxycarbonyl (Boc) protected amine and a terminal hydroxyl group. This bifunctional compound is engineered to provide a versatile, hydrophilic spacer arm for bioconjugation and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science for constructing drug delivery systems, modifying biomolecules, and creating functionalized surfaces.

Application

• Bioconjugation Linker: Used to covalently attach drugs, peptides, or imaging agents to antibodies, proteins, or nanoparticles, enhancing solubility and pharmacokinetics.
• Proteomics Research: Serves as a spacer in solid-phase peptide synthesis (SPPS) and for the modification of amino groups in peptides and proteins.
• Drug Delivery Systems: Incorporated into the design of prodrugs and polymer-drug conjugates to improve bioavailability and target specificity.
• Surface Functionalization: Applied to modify the surface properties of materials (e.g., biosensors, diagnostic chips) to introduce reactive hydroxyl groups for further coupling.
• Cross-linking Agent: Facilitates the formation of hydrogels and polymer networks for tissue engineering and controlled release applications.
• Intermediate for ADC Development: A key building block in the synthesis of Antibody-Drug Conjugates (ADCs), providing a cleavable or non-cleavable linker segment.

Basic Information

Product Name	Bocnh-Peg12-Oh
CAS No.	2218463-36-4
Molecular Formula	C33H67NO15
Molecular Weight	717.88 g/mol
Synonyms	1-Amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontan-38-oic acid, N-(tert-butoxycarbonyl)-; Boc-N-amido-PEG12-OH; Boc-NH-PEG12-OH; tert-Butyl (35-carboxy-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)carbamate; α-Boc-amido-ω-hydroxy-polyethylene glycol; Boc-protected PEG12 amine; Boc-PEG12-acid; (Boc-amino)-PEG12-OH
EINECS	Contact for details

Quality Control

Our Bocnh-Peg12-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.