Description

(S,E)-Methyl 2-Amino-4-(4-Fluorophenyl)But-3-Enoate Hcl is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its core value lies in its defined stereochemistry and functional groups, which are critical for constructing complex molecular architectures with high enantiomeric purity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise stereocontrol is essential.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Building block for creating novel, enantiomerically pure pesticides and herbicides with potentially improved efficacy and environmental profiles.
• Asymmetric Catalysis Research: Used as a substrate or ligand precursor in academic and industrial research focused on developing new catalytic methodologies.
• Peptidomimetics & Bioactive Molecule Construction: Serves as a constrained amino acid derivative for designing enzyme inhibitors and receptor modulators.
• Material Science Precursor: Potential intermediate in the synthesis of specialized polymers or liquid crystals requiring fluorinated aromatic components.

Basic Information

Product Name	(S,E)-Methyl 2-Amino-4-(4-Fluorophenyl)But-3-Enoate Hydrochloride
CAS No.	2209078-25-9
Molecular Formula	C11H13FNO2 • HCl
Molecular Weight	245.68 g/mol (Free base) / 282.14 g/mol (HCl salt)
Synonyms	Methyl (2S,3E)-2-amino-4-(4-fluorophenyl)but-3-enoate hydrochloride; (S,E)-Methyl 2-amino-4-(4-fluorophenyl)-3-butenoate HCl; (2S,3E)-2-Amino-4-(4-fluorophenyl)but-3-enoic acid methyl ester hydrochloride; 4-Fluorophenyl vinyl glycine methyl ester hydrochloride (S,E-isomer); (S,E)-Methyl 4-(4-fluorophenyl)-2-aminobut-3-enoate HCl; CAS 2209078-25-9; Fluorophenyl butenoate amino ester hydrochloride
EINECS	Contact for details

Quality Control

Our (S,E)-Methyl 2-Amino-4-(4-Fluorophenyl)But-3-Enoate Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.