Description

(S)-(Tetrahydro-2H-Pyran-2-Yl)Methanamine Hydrochloride is a high-purity chiral amine hydrochloride salt, serving as a critical building block in advanced organic synthesis. Its defined stereochemistry and protected amine functionality make it an invaluable intermediate for constructing complex molecules with precise spatial orientation. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and chiral ligands.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for transition metal-catalyzed reactions such as hydrogenation and cross-coupling.
• Agrochemical Synthesis: Building block for creating enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Peptidomimetics & Bioactive Molecule Construction: Incorporates the tetrahydro-2H-pyran scaffold into larger molecular architectures to modulate bioavailability and metabolic stability.
• Academic & Process Chemistry Research: A valuable reagent for methodological development in stereoselective synthesis and scale-up process optimization.

Basic Information

Product Name	(S)-(Tetrahydro-2H-Pyran-2-Yl)Methanamine Hydrochloride
CAS No.	2206608-25-3
Molecular Formula	C6H14ClNO
Molecular Weight	151.63 g/mol
Synonyms	(S)-1-((Tetrahydro-2H-pyran-2-yl)methyl)amine hydrochloride; (S)-2-(Aminomethyl)tetrahydro-2H-pyran hydrochloride; (S)-Tetrahydro-2H-pyran-2-ylmethanamine HCl; (S)-THP-Methylamine hydrochloride; (S)-Aminomethyltetrahydropyran hydrochloride; (S)-2-Pyranmethanamine, tetrahydro-, hydrochloride; (S)-(2-Tetrahydropyranyl)methylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-(Tetrahydro-2H-Pyran-2-Yl)Methanamine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.