Description

tert-Butyl (R)-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate is a high-purity, chiral spirocyclic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in the synthesis of novel drug candidates targeting the central nervous system and other therapeutic areas. It is essential for medicinal chemists and process development scientists in pharmaceutical and biotechnology companies who require reliable, high-quality chiral intermediates to accelerate their discovery pipelines and ensure robust synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel chemical space.
• Process Chemistry: Serves as a starting material or advanced intermediate in the development and scale-up of GMP-compliant synthetic routes.
• Ligand and Catalyst Development: Potential precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology: Can be utilized in the design and synthesis of molecular probes for studying biological targets and pathways.
• Academic Research: Employed in university and institutional labs for methodological development and the exploration of new spirocyclic compounds.

Basic Information

Product Name	tert-Butyl (R)-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate
CAS No.	2201785-36-4
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	(R)-tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate; (R)-2-(tert-Butoxycarbonyl)-2,7-diazaspiro[4.4]nonane; (R)-Boc-2,7-diazaspiro[4.4]nonane; (R)-N-Boc-2,7-diazaspiro[4.4]nonane; (R)-2,7-Diazaspiro[4.4]nonane-2-carboxylic acid tert-butyl ester; (R)-2,7-Diazaspiro[4.4]nonane-2-carboxylic acid 1,1-dimethylethyl ester; (R)-2-(tert-Butoxycarbonyl)-2,7-diazaspiro[4.4]nonane hydrochloride (salt form); (R)-Boc-Diazaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our tert-Butyl (R)-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with relevant guidelines and can supply material suitable for use under cGMP conditions for non-clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.