Description

(S)-3,3-Difluoro-Cyclohexylamine Hydrochloride CAS NO 2199497-63-5 is a high-purity, chiral amine hydrochloride salt featuring a difluorinated cyclohexyl backbone. This compound serves as a critical chiral building block and intermediate in modern synthetic chemistry, enabling the introduction of stereochemistry and fluorine atoms into target molecules. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new Active Pharmaceutical Ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the stereochemistry and fluorine atoms can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity in chemical transformations.
• Advanced Material Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials where fluorinated moieties impart desired physical properties.
• Chemical Biology & Proteomics: Useful as a building block for designing molecular probes, enzyme inhibitors, and other tools for biochemical research.

Basic Information

Product Name	(S)-3,3-Difluoro-Cyclohexylamine Hydrochloride
CAS No.	2199497-63-5
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	(1S)-3,3-Difluorocyclohexanamine hydrochloride; (S)-3,3-Difluorocyclohexylamine HCl; (S)-3,3-Difluorocyclohexan-1-amine hydrochloride; (S)-Amino-3,3-difluorocyclohexane hydrochloride; (S)-3,3-Difluorocyclohexylammonium chloride; (S)-3,3-DFCHA HCl; (S)-3,3-Difluoro-1-cyclohexylamine hydrochloride; (S)-3,3-Difluorocyclohexylamine hydrochloride salt
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of (S)-3,3-Difluoro-Cyclohexylamine Hydrochloride is characterized and controlled using advanced analytical techniques, including chiral HPLC, NMR, and mass spectrometry, to guarantee identity, purity, and enantiomeric excess. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.