Description

2-(Piperazin-1-Yl)-5-(Trifluoromethyl)Pyrimidine Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant importance in modern drug discovery. Its core value lies in its unique molecular architecture, combining a piperazine moiety with a trifluoromethylpyrimidine core, which is crucial for modulating the pharmacokinetic and binding properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) for small-molecule drugs.
• Kinase Inhibitor Development: Used in research and production of protein kinase inhibitors, a major class of targeted cancer therapies.
• CNS Drug Research: Employed in the discovery of compounds targeting neurological conditions due to the piperazine scaffold's prevalence in neuroactive molecules.
• Chemical Biology & Proteomics: Acts as a versatile scaffold for creating chemical probes to study enzyme function and protein interactions.
• Agrochemical Research: Utilized in the development of advanced crop protection agents, leveraging the biological activity of pyrimidine derivatives.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2-(Piperazin-1-Yl)-5-(Trifluoromethyl)Pyrimidine Hydrochloride
CAS No.	2197052-44-9
Molecular Formula	C9H12ClF3N4
Molecular Weight	268.67 g/mol
Synonyms	5-(Trifluoromethyl)-2-(1-piperazinyl)pyrimidine hydrochloride; 2-Piperazin-1-yl-5-trifluoromethylpyrimidine HCl; 1-(5-(Trifluoromethyl)pyrimidin-2-yl)piperazine hydrochloride; 5-Trifluoromethyl-2-piperazin-1-yl-pyrimidine hydrochloride; 2-(1-Piperazinyl)-5-(trifluoromethyl)pyrimidine monohydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Piperazin-1-Yl)-5-(Trifluoromethyl)Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and scale-up. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, impurity profile, and residual solvents. Our quality commitment supports compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.