Description

Hydroxy-Peg4-Nitrile is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal hydroxyl group and a nitrile moiety. This compound is a critical building block for the synthesis of advanced bioconjugates and functionalized materials, enabling precise chemical modifications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors for applications such as linker synthesis, surface functionalization, and the development of drug delivery systems.

Application

• Bioconjugation Linker: Serves as a versatile spacer and linker for attaching drugs, dyes, or other functional molecules to proteins, antibodies, or nanoparticles.
• PEGylation Reagent: Used to introduce hydrophilic PEG chains onto therapeutic molecules to improve solubility, stability, and pharmacokinetic profiles.
• Surface Modification: Functionalizes surfaces (e.g., gold, silica) for biosensor development, diagnostic assays, and creating non-fouling coatings.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialized hydrogels and smart polymers.
• Click Chemistry Intermediate: The nitrile group can be transformed into tetrazoles or other functional groups for bioorthogonal conjugation strategies.
• Prodrug Synthesis: Facilitates the design of cleavable prodrug linkers for targeted and controlled drug release.

Basic Information

Product Name	Hydroxy-Peg4-Nitrile
CAS No.	2194563-83-0
Molecular Formula	C13H25NO6
Molecular Weight	291.34 g/mol
Synonyms	4,7,10,13-Tetraoxahexadecanenitrile, 16-hydroxy-; 16-Hydroxy-4,7,10,13-tetraoxahexadecanenitrile; HO-PEG4-CN; Hydroxy-PEG4-cyanide; 2-[2-[2-(2-Cyanoethoxy)ethoxy]ethoxy]ethanol; 3,6,9,12-Tetraoxapentadecanenitrile, 15-hydroxy-; α-Hydro-ω-cyano-tetraethylene glycol; PEG4-OH/CN
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg4-Nitrile CAS NO 2194563-83-0 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your research and cGMP development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.