Description

n-Ethylbicyclo[1.1.1]pentan-1-amine hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique and highly strained bicyclo[1.1.1]pentane (BCP) scaffold. This compound is specifically designed for medicinal chemistry applications, where it serves as a valuable bioisostere for *para*-substituted benzene rings or tert-butyl groups to improve the physicochemical and pharmacokinetic properties of drug candidates. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutics targeting a range of diseases.

Application

• Medicinal Chemistry & Drug Discovery: As a key building block for incorporating the strained BCP motif into lead compounds to enhance metabolic stability, solubility, and membrane permeability.
• Bioisostere Replacement: Used to replace traditional aromatic rings or bulky aliphatic groups in molecular design to reduce lipophilicity and improve overall drug-like properties.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead sections of bifunctional degraders due to its rigid, three-dimensional structure.
• Covalent Inhibitor Synthesis: The amine hydrochloride salt is a precursor for creating covalent binding motifs in enzyme inhibitors.
• Agrochemical Research: Potential application in the development of novel active ingredients with improved environmental profiles.
• Material Science: Exploration of use in the synthesis of novel polymers and advanced materials with unique structural properties.

Basic Information

Product Name	n-Ethylbicyclo[1.1.1]pentan-1-amine hydrochloride
CAS No.	2187435-35-2
Molecular Formula	C7H14ClN
Molecular Weight	147.64 g/mol
Synonyms	1-Amino-1-ethylbicyclo[1.1.1]pentane hydrochloride; 1-Ethylbicyclo[1.1.1]pentan-1-amine hydrochloride; BCP-NEt·HCl; Ethyl-BCP-amine HCl; (1-Ethylbicyclo[1.1.1]pentan-1-yl)amine hydrochloride; n-Ethyl-1-aminobicyclo[1.1.1]pentane hydrochloride
EINECS	Contact for details

Quality Control

Our n-Ethylbicyclo[1.1.1]pentan-1-amine hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.