Description

(2S,4R)-1-tert-Butyl 2-Ethyl 4-Aminopyrrolidine-1,2-Dicarboxylate Hydrochloride is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in modern pharmaceutical synthesis. Its value lies in its defined stereochemistry and protected amine functionality, enabling the efficient construction of complex molecules with high enantiomeric purity. This advanced intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially protease inhibitors and other biologically active molecules.
• Asymmetric Synthesis: Utilized as a stereochemically defined scaffold for constructing complex natural products and medicinal compounds.
• Peptidomimetics Research: Serves as a constrained proline analogue in the design and development of peptide-based therapeutics.
• Chemical Biology Probes: Used in the development of tool compounds for studying enzyme mechanisms and biological pathways.
• Catalyst Ligand Precursor: Acts as a starting material for the synthesis of chiral ligands used in asymmetric catalysis.
• Process Chemistry Development: Employed in route scouting and optimization for scalable API manufacturing processes.

Basic Information

Product Name	(2S,4R)-1-tert-Butyl 2-Ethyl 4-Aminopyrrolidine-1,2-Dicarboxylate Hydrochloride
CAS No.	2187426-87-3
Molecular Formula	C13H25N2O4•HCl
Molecular Weight	308.81 g/mol
Synonyms	1-Boc-2-Ethyl-4-aminopyrrolidine-2-carboxylate hydrochloride; (2S,4R)-1-(tert-Butoxycarbonyl)-2-(ethoxycarbonyl)-4-aminopyrrolidine hydrochloride; 4-Amino-1-Boc-2-ethoxycarbonylpyrrolidine HCl; (2S,4R)-1-tert-Butoxycarbonyl-2-ethoxycarbonyl-4-aminopyrrolidine hydrochloride; 1-N-Boc-2-ethyl-4-aminopyrrolidine-2-carboxylic acid ester hydrochloride; (2S,4R)-4-Amino-1-Boc-pyrrolidine-2-carboxylic acid ethyl ester hydrochloride; tert-Butyl (2S,4R)-2-(ethoxycarbonyl)-4-aminopyrrolidine-1-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our production of (2S,4R)-1-tert-Butyl 2-Ethyl 4-Aminopyrrolidine-1,2-Dicarboxylate Hydrochloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.