Description

n-(Acid-Peg3)-n-Bis(Peg3-Amine) is a symmetrical, multi-armed polyethylene glycol (PEG)-based bifunctional linker featuring one terminal carboxylic acid group and two primary amine termini, each separated by three ethylene oxide units (PEG3). This architecture enables precise, orthogonal conjugation in demanding bioconjugation and nanomaterial functionalization workflows where controlled stoichiometry and hydrophilic spacer length are critical. It is widely utilized by pharmaceutical R&D teams, diagnostic reagent manufacturers, and advanced materials scientists requiring high-purity, well-defined PEG spacers with balanced reactivity and solubility. The compound is identified by CAS NO 2183440-35-7.

Application

• Site-specific antibody–drug conjugate (ADC) linker development, enabling controlled payload attachment via amine-acid coupling
• Surface functionalization of nanoparticles (e.g., gold, silica, liposomes) for improved biocompatibility and targeting ligand immobilization
• Preparation of PEGylated peptides and proteins to enhance pharmacokinetic profiles and reduce immunogenicity
• Synthesis of stimuli-responsive hydrogels and crosslinked biomaterials leveraging acid–amine condensation or NHS-ester derivatization
• Building block for dendritic PEG architectures and multivalent scaffolds in vaccine adjuvant design
• Chelator–PEG conjugation in radiopharmaceutical development (e.g., DOTA/NOTA–PEG–antibody constructs)

Basic Information

Product Name	n-(Acid-Peg3)-n-Bis(Peg3-Amine)
CAS No.	2183440-35-7
Molecular Formula	C27H56N2O14
Molecular Weight	632.74 g/mol
Synonyms	Tri-PEG3 acid-amine; N-(Carboxymethyl-PEG3)-N,N-bis(aminopropyl-PEG3); 3-[2-(2-{2-[(2-aminoethoxy)ethoxy]ethoxy}ethylamino)-2-oxoethyl]-2-{2-[2-(2-{2-[(2-aminoethoxy)ethoxy]ethoxy}ethylamino)-2-oxoethyl]amino]-2-oxoethyl}propanoic acid; Acid-PEG3-NH-PEG3-NH-PEG3-COOH; Bis(aminopropyl-PEG3)-acid; n-(Carboxy-PEG3)-n,n-bis(amino-PEG3); PEG3-acid-PEG3-amine-PEG3-amine; Tri-arm PEG linker (COOH–NH2–NH2)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is verified for identity, purity, moisture content, and residual solvents using validated methods including HPLC, NMR, and FTIR. Certificates of Analysis (COA) are available upon request and include assay (≥95.0%), residual water (≤0.5%), and heavy metals (≤10 ppm). Manufacturing adheres to ISO 9001 and cGMP-aligned practices suitable for research and preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent degradation. Due to its hygroscopic nature, minimize exposure to ambient humidity; allow container to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or viscous solid
Identification (FTIR)	Conforms to reference spectrum
Identification (NMR)	Conforms to reference 1H NMR spectrum
Assay (HPLC)	≥95.0%
Residual Solvents (GC)	MeOH ≤0.3%; CH2Cl2 ≤0.06%
Water Content (Karl Fischer)	≤0.5%
Heavy Metals	≤10 ppm
pH (1% w/v aqueous solution)	5.5–7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.