Description

3-Bromo-5,6,7,8-Tetrahydro-1,7-Naphthyridine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate and building block of significant interest in modern organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs), particularly within therapeutic areas requiring complex heterocyclic scaffolds. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for synthesizing potential drug candidates, leveraging its reactive bromine and stable dihydrochloride salt form for further functionalization.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• Organic Synthesis Reagent: Used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions to introduce the naphthyridine moiety into more complex molecules.
• Chemical Research & Development: Serves as a standard or reference compound in academic and industrial research exploring new heterocyclic chemistry.
• Agrochemical Synthesis: Potential intermediate in the development of new crop protection agents and herbicides.
• Material Science Precursor: Can be utilized in the synthesis of organic ligands for catalysts or functional materials.

Basic Information

Product Name	3-Bromo-5,6,7,8-Tetrahydro-1,7-Naphthyridine Dihydrochloride
CAS No.	2177267-75-1
Molecular Formula	C8H10BrN2·2HCl
Molecular Weight	308.00 g/mol (approx.)
Synonyms	3-Bromo-5,6,7,8-tetrahydro-1,7-naphthyridine hydrochloride (1:2); 3-Bromo-1,2,3,4-tetrahydro-1,7-naphthyridine dihydrochloride; 3-Bromo-5,6,7,8-tetrahydro[1,7]naphthyridine dihydrochloride; 2177267-75-1; 3-Bromo-5,6,7,8-tetrahydro-1,7-naphthyridine HCl salt
EINECS	Contact for details

Quality Control

Our 3-Bromo-5,6,7,8-Tetrahydro-1,7-Naphthyridine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.