Description

3-Fluoroquinoline-8-Carbonitrile is a high-value, fluorinated heterocyclic building block with the CAS registry number 2177264-04-7. This compound is critical for medicinal chemistry research and development, offering a versatile scaffold for the synthesis of novel pharmaceutical candidates. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity of the quinoline core and fluorine substitution.
• Material Science: Acts as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient character.
• Ligand Synthesis: Employed in the preparation of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: A valuable substrate for further functionalization via cross-coupling reactions, nucleophilic substitutions, and cyano group transformations.

Basic Information

Product Name	3-Fluoroquinoline-8-Carbonitrile
CAS No.	2177264-04-7
Molecular Formula	C10H5FN2
Molecular Weight	172.16 g/mol
Synonyms	8-Cyano-3-fluoroquinoline; 3-Fluoro-8-quinolinecarbonitrile; Quinoline-8-carbonitrile, 3-fluoro-; 3-Fluoroquinoline-8-carbonitrile; 2177264-04-7; 3-Fluoro-8-cyanoquinoline; 3-Fluoro-8-quinolyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoroquinoline-8-Carbonitrile is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.