Description

Methyl 3-(2-{2-[2-(Aminooxy)Ethoxy]Ethoxy}Ethoxy)Propanoate Hydrochloride is a specialized bifunctional linker compound featuring a terminal aminooxy group and a methyl ester. This molecular architecture is engineered to enable efficient and selective conjugation chemistry, particularly for the modification of biomolecules and surfaces. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-purity building blocks for drug discovery, bioconjugation, and advanced material science applications.

Application

• Bioconjugation Reagent: Used for site-specific labeling and crosslinking of proteins, antibodies, and oligonucleotides via oxime ligation with carbonyl groups (ketones or aldehydes).
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of antibody-drug conjugates (ADCs), targeted therapeutics, and prodrugs.
• Surface Functionalization: Enables the modification of nanoparticles, biosensors, and chromatography media with aminooxy-reactive handles for subsequent biomolecule immobilization.
• Polymer Chemistry: Acts as a functional monomer or initiator for creating smart polymers and hydrogels with reactive pendant groups for further chemical modification.
• Chemical Biology Probes: Utilized in the development of activity-based probes and diagnostic agents for studying biological processes.
• Material Science: Facilitates the creation of functionalized coatings and thin films with specific biorecognition properties.

Basic Information

Product Name	Methyl 3-(2-{2-[2-(Aminooxy)Ethoxy]Ethoxy}Ethoxy)Propanoate Hydrochloride
CAS No.	2173992-41-9
Molecular Formula	C12H26ClNO7
Molecular Weight	331.79 g/mol
Synonyms	Methyl 3-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]propanoate hydrochloride; Amino-PEG3-methyl ester hydrochloride; O-(2-Aminooxyethyl)-O'-(2-carbomethoxyethyl)triethylene glycol hydrochloride; Hydrochloride salt of Methyl 3,6,9-trioxa-12-azadodecanoate; Aminooxy-PEG3-C2-methyl ester HCl; AOP3-ME HCl; (Aminooxy)tri(ethylene glycol)propionic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 3-(2-{2-[2-(Aminooxy)Ethoxy]Ethoxy}Ethoxy)Propanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Keep container tightly sealed under an inert atmosphere when not in use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.