Description

tert-Butyl trans-3-Aminocyclobutane-1-Carboxylate Hydrochloride is a high-purity, protected amino acid derivative essential for advanced pharmaceutical research and development. This compound serves as a critical chiral building block and intermediate in the synthesis of complex drug candidates, particularly in medicinal chemistry programs. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetics & Constrained Peptides: Used to introduce the rigid, three-dimensional cyclobutane scaffold into peptide backbones to enhance metabolic stability and receptor selectivity.
• PROTAC & Molecular Glue Development: Serves as a versatile linker component in the design of proteolysis-targeting chimeras (PROTACs) and other bifunctional molecules.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and probes for studying enzyme function and biological pathways.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material for the stereoselective construction of complex natural products and analogs.
• Material Science Research: Potential monomer for creating novel polymers with specific structural and functional properties.

Basic Information

Product Name	tert-Butyl trans-3-Aminocyclobutane-1-Carboxylate Hydrochloride
CAS No.	2173637-24-4
Molecular Formula	C9H18ClNO2
Molecular Weight	207.70 g/mol
Synonyms	trans-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid hydrochloride; 1,1-Dimethylethyl (1r,3r)-3-aminocyclobutanecarboxylate hydrochloride; tert-Butyl (1r,3r)-3-aminocyclobutanecarboxylate hydrochloride; (1r,3r)-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid hydrochloride; BOC-trans-3-ACBC-HCl; trans-3-BOC-Aminocyclobutanecarboxylic Acid Hydrochloride; (1R,3R)-3-[(tert-Butoxycarbonyl)amino]cyclobutanecarboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our tert-Butyl trans-3-Aminocyclobutane-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.