Description

2-[(2R)-Azetidin-2-Yl]Propan-2-Ol Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value for the research and development of novel active pharmaceutical ingredients (APIs), particularly in the areas of neurology and metabolic diseases. It is primarily needed by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers engaged in the synthesis of complex, stereochemically defined molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic agents.
• Process Development: Serves as a starting material or advanced intermediate in scaling up synthetic routes under current Good Manufacturing Practice (cGMP) guidelines.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor to introduce the azetidine moiety with defined stereochemistry into complex molecular architectures.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	2-[(2R)-Azetidin-2-Yl]Propan-2-Ol Hydrochloride
CAS No.	2173637-17-5
Molecular Formula	C6H14ClNO
Molecular Weight	151.64 g/mol
Synonyms	(2R)-2-(2-Hydroxypropan-2-yl)azetidine hydrochloride; 2-(2R)-Azetidin-2-ylpropan-2-ol hydrochloride; 2-Propan-2-ol, 2-[(2R)-azetidin-2-yl]-, hydrochloride; 1-(2-Hydroxy-2-methylpropyl)azetidine hydrochloride (racemic reference); (R)-2-(2-Hydroxy-2-methylpropyl)azetidine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-[(2R)-Azetidin-2-Yl]Propan-2-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.