Description

m-Peg3-S-Peg2-Oh CAS NO 2173095-09-3 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a thioether (sulfide) linkage and a terminal hydroxyl group, designed as a versatile linker for bioconjugation and pharmaceutical applications. This compound is engineered to provide a hydrophilic spacer arm with enhanced stability compared to pure PEG chains, facilitating the attachment of biomolecules, drugs, or imaging agents. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceutical development, ADC (Antibody-Drug Conjugate) synthesis, and advanced material science.

Application

• Bioconjugation Linker: For site-specific modification of proteins, peptides, and antibodies to improve solubility, stability, and pharmacokinetics.
• ADC (Antibody-Drug Conjugate) Payload Attachment: Serves as a cleavable or non-cleavable linker component for connecting cytotoxic drugs to monoclonal antibodies.
• PEGylation Reagent: Used to introduce PEG chains onto drug molecules or surfaces to reduce immunogenicity and prolong circulation half-life.
• Crosslinking Agent: For creating hydrogel networks or modifying biomaterial surfaces due to its reactive thioether and hydroxyl termini.
• Polymer Chemistry Building Block: As a monomer or macromonomer in the synthesis of functionalized, biocompatible polymers.
• Diagnostic Probe Synthesis: In the development of contrast agents and fluorescent probes for imaging applications.

Basic Information

Product Name	m-Peg3-S-Peg2-Oh
CAS No.	2173095-09-3
Molecular Formula	C13H28O7S
Molecular Weight	328.42 g/mol
Synonyms	1-(2-(2-(2-Methoxyethoxy)ethylthio)ethoxy)ethoxy)ethanol; 3,6,9-Trioxa-12-thiapentadecan-1-ol, 15-methoxy-; mPEG3-S-PEG2-OH; Methoxy-PEG3-thio-PEG2-OH; Heterobifunctional PEG sulfide alcohol; Thioether-PEG-alcohol; PEG-based heterobifunctional crosslinker
EINECS	Contact for details

Quality Control

Our m-Peg3-S-Peg2-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight Verification (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.