Description

[(1R)-3,3-Difluorocyclopentyl]Methanamine Hydrochloride is a high-purity chiral amine hydrochloride salt, a critical building block in modern pharmaceutical research and development. Its value lies in its unique, stereochemically defined difluorocyclopentyl structure, which is instrumental for modulating the pharmacokinetic and binding properties of drug candidates. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutics, particularly in areas targeting central nervous system (CNS) disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies to explore new chemical entities, leveraging the fluorine atoms for metabolic stability and lipophilicity control.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of target drug molecules.
• Bioconjugation & Probe Development: The primary amine functionality allows for conjugation to create molecular probes for biological target identification and validation.
• Library Synthesis: A valuable scaffold for generating focused compound libraries in high-throughput screening campaigns.

Basic Information

Product Name	[(1R)-3,3-Difluorocyclopentyl]Methanamine Hydrochloride
CAS No.	2173052-22-5
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	(1R)-3,3-Difluorocyclopentylmethanamine hydrochloride; (R)-3,3-Difluorocyclopentylmethanamine HCl; 1-((1R)-3,3-Difluorocyclopentyl)methanamine hydrochloride; (1R)-3,3-Difluorocyclopentanemethanamine hydrochloride; (R)-1-(3,3-Difluorocyclopentyl)methanamine hydrochloride; (R)-3,3-Difluorocyclopentylmethylamine hydrochloride; (1R)-3,3-Difluorocyclopentylmethylamine HCl
EINECS	Contact for details

Quality Control

Every batch of [(1R)-3,3-Difluorocyclopentyl]Methanamine Hydrochloride is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and enantiomeric excess meet the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) including results for assay, chiral purity, related substances, and residual solvents is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.